@import url('https://fonts.googleapis.com/css2?family=DM+Sans:wght@400;500;600;700&family=Manrope:wght@400;500;600;700;800&display=swap');
:root{--bg:#f7f8f4;--ink:#253d34;--muted:#7b8780;--line:#e1e6dd;--green:#367e5d;--orange:#c8754e}*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--ink);font:13px 'DM Sans',sans-serif}button,input,select{font:inherit}button{cursor:pointer;color:inherit}button:focus-visible,input:focus-visible,select:focus-visible,canvas:focus-visible{outline:2px solid #bb744c;outline-offset:3px}header{height:80px;display:flex;align-items:center;justify-content:space-between;border-bottom:1px solid var(--line);padding:0 28px;background:#fcfdf9}.brand{display:flex;align-items:center;gap:12px;text-decoration:none;color:var(--ink);font-size:17px;font-weight:800;letter-spacing:2px}.logo{font-size:33px;color:var(--green)}.brand small{font-size:8px;letter-spacing:1.6px;color:var(--muted);border-left:1px solid var(--line);padding:8px 12px}nav{display:flex;gap:18px}.nav{border:0;background:none;font-size:12px;padding:29px 6px}.nav.active{border-bottom:2px solid var(--green)}.new{font-size:8px;background:#e9eee1;padding:4px;margin-left:4px}.button{border:1px solid var(--line);background:white;border-radius:7px;padding:10px 15px}.button span{margin-left:16px}main{display:grid;grid-template-columns:264px minmax(390px,1fr) 280px;max-width:1900px;margin:auto}.left,.right{padding:30px 22px;border-right:1px solid var(--line)}.right{border-left:1px solid var(--line);border-right:0;background:#fcfdf9}.eyebrow{font-size:9px;letter-spacing:1.8px;font-weight:700;color:#8a968c}h1{font-family:Manrope,sans-serif;font-size:27px;letter-spacing:-1.2px;margin:12px 0}p{line-height:1.65}.intro{color:var(--muted);font-size:12px;margin-bottom:25px}.tabs{display:flex;border-bottom:1px solid var(--line);margin-bottom:17px}.tabs button{border:0;background:none;padding:12px 0;width:50%;color:var(--muted);font-size:11px}.tabs button.selected{color:var(--green);border-bottom:2px solid var(--green);font-weight:700}.tabs span{font-size:9px;margin-left:4px;background:#e9eee5;padding:2px 4px;border-radius:3px}.search{display:flex;gap:8px;border:1px solid var(--line);padding:9px;border-radius:6px;background:white}.search input{border:0;width:100%;outline:none;background:none;font-size:11px}.minirow{display:flex;gap:8px;margin:15px 0;font-size:9px;color:var(--muted)}.minirow span{margin-right:auto}.minirow button{background:none;border:0;padding:0;font-size:9px}.grouphead{font-size:8px;letter-spacing:1.5px;color:#929b91;margin:20px 0 8px}.structure{display:flex;align-items:center;gap:8px;min-height:34px;border-radius:5px;padding:3px 5px;margin-bottom:2px}.structure.active{background:#e8eee3}.structure button{border:0;background:none;text-align:left;flex:1;font-size:11px;padding:5px 0}.dot{width:6px;height:6px;border-radius:50%;flex-shrink:0}.toggle{appearance:none;width:25px;height:14px;border-radius:10px;background:#d8ddd4;position:relative;cursor:pointer;margin:0;flex-shrink:0}.toggle:checked{background:#5c8b6a}.toggle:after{content:'';position:absolute;width:10px;height:10px;left:2px;top:2px;background:white;border-radius:50%;transition:.15s}.toggle:checked:after{left:13px}#structures{max-height:610px;overflow:auto;scrollbar-width:thin}.leftfooter{font-size:9px;color:var(--muted);margin-top:24px;display:flex;gap:6px;align-items:center}.statusdot{display:inline-block;width:5px;height:5px;border-radius:50%;background:#5d9370;margin-right:5px}.workspace{padding:30px 28px 15px;min-width:0}.viewhead{display:flex;justify-content:space-between;align-items:center}h2{font-family:Manrope,sans-serif;font-size:23px;letter-spacing:-.7px;font-weight:500;margin:8px 0}.pill{font-size:8px;letter-spacing:1px;border:1px solid #d4dfcf;border-radius:20px;padding:7px 10px;background:#edf2e8;white-space:nowrap}.pill.changed{background:#f6e9de;color:#a76242;border-color:#e8d2be}.canvaswrap{height:min(59vw,535px);min-height:380px;position:relative;margin-top:16px;background:radial-gradient(ellipse at center,#e5eddd 0%,#f4f6ee 62%,#f7f8f4 85%);overflow:hidden;border:1px solid #e7ebe1;border-radius:10px}canvas{width:100%;height:100%;display:block;cursor:grab;touch-action:none}.viewtop{position:absolute;top:17px;left:17px;right:17px;display:flex;justify-content:space-between;align-items:center;pointer-events:none}.caption{font-size:8px;letter-spacing:1px;color:#84917e}.floating{pointer-events:auto;border:1px solid #dce3d6;background:#fafcf7dd;border-radius:5px;padding:7px 9px;font-size:9px}.floating.on{background:#354d3d;color:white}.orientation{position:absolute;bottom:45px;left:20px;font-size:9px;color:#8c9c86;line-height:1.8}.viewhint{position:absolute;bottom:17px;left:0;right:0;text-align:center;color:#9ba492;font-size:9px;pointer-events:none}.viewhint i{margin:0 8px}.viewtools{position:absolute;right:15px;bottom:42px;display:flex;flex-direction:column;background:#fcfdf8;border:1px solid var(--line);border-radius:7px}.viewtools button{border:0;background:none;padding:7px 11px;font-size:17px}.toolbar{display:flex;align-items:center;gap:17px;padding:18px 0;border-bottom:1px solid var(--line);flex-wrap:wrap;font-size:10px}.check{display:flex;align-items:center;gap:6px;cursor:pointer}.check input{accent-color:#477c53;width:12px;height:12px}.opacity{display:flex;align-items:center;gap:5px;margin-left:auto}input[type=range]{accent-color:#557e5e;height:3px;width:70px}.quiet{border:0;background:none;color:#7b877a;font-size:10px;padding:5px}.story{display:flex;align-items:center;gap:25px;padding:24px 0}.story h3{font-size:18px;font-family:Manrope,sans-serif;font-weight:500;margin:8px 0}.story p{color:var(--muted);font-size:11px;margin:0;max-width:500px}.circlebutton{background:#e6ecdf;border:1px solid #d4decb;border-radius:50%;font-size:20px;flex-shrink:0;width:41px;height:41px}.footnote{border-top:1px solid var(--line);padding-top:14px;color:#8e9889;font-size:8px;line-height:1.7}.divider{height:1px;background:var(--line);margin:24px 0}.inspectoricon{height:83px;margin:15px 0;background:#eef2e7;border-radius:8px;display:flex;align-items:center;justify-content:center;font-size:43px;color:#9e9f63}.inspectorTitle{font-family:Manrope,sans-serif;font-size:21px;margin:12px 0 6px}.tag{font-size:8px;letter-spacing:1px;color:#829176;text-transform:uppercase}.description{color:#7b8677;font-size:11px}.subparts{display:flex;flex-wrap:wrap;gap:5px;margin:12px 0}.subparts span{border:1px solid #e3e7dc;border-radius:4px;padding:4px 6px;font-size:9px;color:#7a8671}.inspectButtons{display:flex;gap:5px}.inspectButtons button{flex:1;background:#edf2e7;border:1px solid #dce5d4;border-radius:4px;font-size:10px;padding:8px}.source{font-size:9px;color:#628069;display:inline-block;margin-top:12px}.selectlabel{display:block;font-size:10px;margin-top:14px}.selectlabel select{display:block;width:100%;border:1px solid var(--line);border-radius:4px;padding:8px;background:#fff;margin:7px 0;font-size:11px}.special{font-size:11px;margin-top:20px}.smallnote{font-size:9px;line-height:1.7;color:#92998a}.selectlabel input{display:block;width:100%;margin:12px 0 20px}.wide{width:100%;padding:10px;border:1px solid #d8e0d0;border-radius:5px;background:#edf2e6;font-size:10px;margin-top:10px}.readout{display:flex;justify-content:space-between;gap:8px;padding:11px 0;border-bottom:1px solid #edf0e8;font-size:10px}.readout span{color:#7c8978}.readout strong{font-size:9px;font-weight:500;text-align:right}.readout.changed strong{color:#bd714d}.actions{display:flex;justify-content:space-between;margin-top:20px}.panelnote{font-size:10px;color:var(--muted)}.driver{border:1px solid var(--line);border-radius:6px;padding:12px;margin:10px 0;background:#fcfdf9}.driver.on{border-color:#d5af94;background:#f8f0e7}.driverTop{display:flex;justify-content:space-between;align-items:center}.gene{font-family:Manrope,sans-serif;font-weight:700;font-size:15px}.driver .kind{display:block;font-size:8px;color:#bd7b58;letter-spacing:.4px;margin-top:3px}.driver p{font-size:10px;color:var(--muted);margin-bottom:0}.driver .toggle:checked{background:#c28158}#labels{pointer-events:none;position:absolute;inset:0}.label{position:absolute;font-size:8px;color:#637958;background:#fbfcf4db;padding:4px 6px;border:1px solid #d9e1ce;border-radius:3px;white-space:nowrap}.label:before{content:'';position:absolute;left:-16px;width:16px;top:50%;height:1px;background:#a9b99b}#compareTag{position:absolute;top:62px;left:20px;font-size:9px;letter-spacing:1px}#compareTag span{display:block;letter-spacing:0;font-size:8px;color:var(--muted);margin-top:5px}#notice{font-size:10px;color:var(--green);min-height:20px;padding-top:10px}dialog{border:1px solid var(--line);border-radius:12px;max-width:640px;width:90vw;padding:32px;color:var(--ink);background:#fafcf6}dialog::backdrop{background:#203a2c77;backdrop-filter:blur(4px)}dialog p{font-size:12px;color:#71816e}.close{float:right;border:0;background:none;font-size:24px}dialog a{color:#527e57;font-size:11px}dialog li{padding:5px}button:hover{filter:brightness(.96)}[hidden]{display:none!important}@media(min-width:1500px){main{grid-template-columns:285px minmax(390px,1fr) 300px}.canvaswrap{height:610px}}@media(max-width:1100px){main{grid-template-columns:220px minmax(300px,1fr)}.right{grid-column:1/-1;display:grid;grid-template-columns:1fr 1fr;gap:16px;padding:24px}.right>.eyebrow,.right>.divider{display:none}.workspace{padding:25px 20px}.left{padding:25px 16px}.brand small{display:none}header{padding:0 20px}nav{gap:8px}}@media(max-width:700px){header{height:auto;min-height:70px;flex-wrap:wrap;padding:15px}.brand{font-size:13px}nav{order:3;width:100%;justify-content:center}.nav{padding:14px 8px}.button{font-size:10px}main{display:flex;flex-direction:column}.workspace{order:0;padding:22px 15px}.left{order:1;border-top:1px solid var(--line)}.right{order:2;display:block}#structures{max-height:340px;display:grid;grid-template-columns:1fr 1fr;gap:0 14px}.grouphead{grid-column:1/-1}.canvaswrap{height:440px;min-height:0}.caption{font-size:6px}.toolbar{gap:10px}.opacity{margin-left:0}.viewhead h2{font-size:21px}.viewhint{font-size:8px}.footnote{font-size:9px}.leftfooter{margin:15px 0}.intro{margin-bottom:12px}.right{padding:25px}.right>.eyebrow{display:block}.inspectoricon{height:65px}#drivers{display:grid;grid-template-columns:1fr 1fr;gap:10px}.driver{margin:0}.viewtop{left:10px;right:10px}.floating{font-size:8px}.smallnote{font-size:10px}}

.variantSpotlight{padding:15px;background:#f0eee3;border:1px solid #e2dac4;border-radius:8px;margin-bottom:26px}.variantRow{display:flex;justify-content:space-between;align-items:center}.variantRow h3{font-size:17px;font-weight:500;margin:10px 0 4px}.variantRow strong{color:#af744d}.variantRow span{font-size:9px;color:#958d78}.variantRow .toggle:checked{background:#bd7d54}.residueRow{display:flex;gap:12px;align-items:center;margin:16px 0}.residueRow b{display:block;font-size:9px;letter-spacing:1.5px}.residueRow span{display:block;font-size:9px;color:#92917d;margin-top:4px}#residueSymbol{background:#dfe7d5;border:1px solid #ccd8bf;border-radius:50%;width:42px;height:42px;display:flex;align-items:center;justify-content:center;font-family:serif;font-size:25px}#residueSymbol.mutant{background:#edd0b8;border-color:#d7aa86;color:#a26741}.variantSpotlight button{border:0;border-top:1px solid #dedbc9;padding:10px 0 0;background:none;width:100%;text-align:left;font-size:10px;color:#8c795c}.driver.featured{border-color:#c5ad83;background:#f2eee2}.variantMore{display:block;background:none;border:0;padding:8px 0 0;font-size:10px;color:#a06f46}.residueCompare{display:grid;grid-template-columns:1fr 1fr;gap:15px;margin:22px 0}.residueCompare>div{border:1px solid #dfe4d6;border-radius:8px;padding:20px;background:#edf2e6}.residueCompare>div:last-child{background:#f5e9dc;border-color:#e6d2b9}.residueCompare strong{display:block;font-size:58px;font-family:serif;font-weight:400;margin-top:14px}.residueCompare small{font:12px sans-serif;color:#8f9981}.residueCompare h3{margin:0}.variantLinks{display:flex;flex-direction:column;gap:10px;margin:20px 0}.variantSwitch{padding:15px;background:#f0f3e9;border-radius:6px}.right .description{margin-bottom:10px}.right .inspectoricon{height:55px}

/* Anatomical viewer v2 */
main{grid-template-columns:245px minmax(420px,1fr) 280px;max-width:2000px}.workspace{padding:24px 22px 15px}.canvaswrap{height:620px;min-height:470px;background:#091015;border-color:#263835;border-radius:0 0 10px 10px;margin-top:0}canvas{background:#091015}.viewtop .caption{color:#c0d1c4;font-size:8px}.viewtop .statusdot{background:#abc3a2}.floating{background:#182724e6;color:#ccd8cb;border-color:#3a4a40}.floating.on{background:#afc3a2;color:#17251f}.viewhint{color:#93a495}.viewtools{background:#162421e8;border-color:#34473c}.viewtools button{color:#cad8c5}.orientation{color:#94a58f}.label{color:#e3e7d7;background:#172421d9;border-color:#54624c;border-radius:3px;font-size:9px;padding:5px 7px}.label:before{background:#a2af8c}.layerstrip{display:flex;align-items:center;gap:22px;border:1px solid #dce3d4;border-radius:8px;padding:14px 16px;margin:20px 0 12px;background:#eff3e9}.layerstrip strong{display:block;font-size:12px;margin-top:5px;font-weight:500;min-width:145px}.layerstrip input{flex:1;width:100%;min-width:70px}.layerEnds{font-size:8px;letter-spacing:1px;color:#8e9b82}.focusbar{display:flex;align-items:center;gap:10px;padding:12px 15px;background:#172521;color:#cbd7c6;border:1px solid #2c4036;border-radius:9px 9px 0 0;font-size:10px}.focusbar>span{margin-right:auto}.focusbar select{font-size:10px;color:#cfdbc8;background:#21362b;border:1px solid #3f5343;border-radius:4px;padding:6px;max-width:200px}.focusbar button{font-size:10px;background:none;border:0;color:#c0d0b8}.sectionbar{display:flex;gap:25px;flex-wrap:wrap;padding:15px 2px;border-bottom:1px solid var(--line);font-size:9px;color:#718267}.sectionbar label{display:flex;gap:10px;align-items:center}.sectionbar input{width:90px}#meshStats{margin-left:auto;font-size:8px;color:#8e9a86}.subparts{display:block;margin:14px 0}.subparts label{display:flex;align-items:center;gap:7px;font-size:10px;padding:7px 0;border-bottom:1px solid #e8ecdf;color:#758269}.subparts input{accent-color:#578362;width:12px;height:12px}.inspectoricon{display:none}.variantSpotlight{margin-bottom:22px}.right{padding:24px 18px}.right .description{font-size:11px}.right .inspectorTitle{font-size:19px}.left{padding:26px 17px}#structures{max-height:750px}#renderError{position:absolute;inset:30%;color:#fff;background:#533b37;padding:20px;z-index:10}#compareTag{color:#e0e5d7}#compareTag span{color:#9db09d}.toolbar{font-size:10px;gap:13px}.story{padding:22px 0}.viewhead h2{font-size:24px}
@media(min-width:1600px){main{grid-template-columns:275px minmax(500px,1fr) 295px}.canvaswrap{height:700px}}
@media(max-width:1100px){main{grid-template-columns:210px minmax(340px,1fr)}.canvaswrap{height:580px}.right{display:block;columns:2;column-gap:32px}.right>section,.right>#inspector{break-inside:avoid}.layerEnds{display:none}.workspace{padding:24px 17px}.focusbar{flex-wrap:wrap}.focusbar>span{width:100%}.sectionbar{gap:15px}.variantSpotlight{break-inside:avoid}}
@media(max-width:700px){main{display:flex}.canvaswrap{height:530px;min-height:0}.workspace{padding:20px 10px}.layerstrip{padding:13px 10px;gap:12px}.layerstrip strong{min-width:125px;font-size:11px}.focusbar>span{width:auto;font-size:9px}.focusbar select{max-width:150px}.right{columns:1;padding:24px}.sectionbar{font-size:9px;gap:14px}.sectionbar input{width:70px}#meshStats{width:100%;margin:0}#structures{max-height:420px}.viewtop .caption{font-size:7px}.layerstrip .eyebrow{font-size:8px}}

/* Ultrastructure explorer */
.materialbar{display:flex;gap:14px;align-items:center;margin:18px 0 0;padding:12px;background:#e9eeea;border:1px solid #d3dcd4;border-radius:7px;color:#5d6d65;font-size:10px}.materialbar label{display:flex;gap:7px;align-items:center}.materialbar select{background:#f6f8f4;border:1px solid #c8d2c9;padding:6px;border-radius:3px;font-size:10px;color:#43574b}.materialbar button{margin-left:auto;padding:7px 10px;border:1px solid #bdcabc;border-radius:3px;background:transparent;color:#43574b;font-size:10px}.coverage{display:grid;gap:5px;margin-top:16px;border-top:1px solid #d8dfd3;padding-top:14px;font-size:10px;line-height:1.6;color:#7b887b}.coverage b{color:#506751;font-weight:500}.coverage span{font-size:9px}.layerstrip{margin-top:10px}.immersive main{grid-template-columns:minmax(0,1fr) 280px}.immersive .left{display:none}.immersive .canvaswrap{height:calc(100vh - 220px);min-height:600px}.immersive .workspace{min-width:0}.canvaswrap{isolation:isolate}.canvaswrap canvas{touch-action:none}.viewtop{pointer-events:none}.viewtop button{pointer-events:auto}@media(max-width:700px){.materialbar{flex-wrap:wrap;gap:8px}.materialbar select{max-width:140px}.immersive main{display:flex}.immersive .canvaswrap{min-height:500px;height:70vh}}